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Studies have shown that extracellular vesicle-mediated delivery of circDYM can treat depression by inhibiting microglial activation and binding transcription factor TATA-box binding protein-related factor 1 to suppress neuroinflammation 169

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As a result, SASP can propagate widely and contribute to tissue dysfunction, including chronic inflammation, fibrosis, and the progression of neurodegenerative diseases (Nelson et al., 2012)

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These MSNs subsequently project to the prefrontal cortex (PFC) and hypothalamus (HY), facilitating the observed functional improvements