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[DOI] [PubMed] [Google Scholar] 135.Chauhan A, Gu F, Essa MM, et al

4a,b and Supplementary Fig

In contrast, the inhibition of SIRT1 significantly diminished the protective effects of melatonin, suggesting that melatonin plays a crucial role in maintaining mitochondrial function to suppress oxidative stress by modulating the level of SIRT1 in OA progression (137)

Tb4s effect on immune system regulation also makes it valuable for addressing numerous conditions

Following an 8-week intervention period, the ATD cohort demonstrated the most pronounced enhancement in femoral BMD and serum 25(OH)D concentrations, in addition to the most considerable decrease in PTH levels