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Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway

Volume of Distribution The apparent volume of distribution reflects a balance between binding to tissues, which decreases plasma concentration and makes the apparent volume larger, and binding to plasma proteins, which increases plasma concentration and makes the apparent volume smaller

Determination of optimal drug concentrations for CRISPR screen HEK293 cells were seeded in 6-well plates at a density optimized to remain below 90% confluency after 72 h of treatment with minimal concentrations of drugs either inhibiting mitochondrial translation (chloramphenicol) or inducing mitochondrial mistranslation (actinonin)

10.1007/s00702-023-02635-4 J Neural Transm (Vienna)

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