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As shown in Table 4, supplementation of doses higher than 75 mg/kg bw show an adverse effect on the kidneys

For instance, indole-3-propionic acid (IPA) is a microbial metabolite with antioxidant properties that can cross the BBB

Atherosclerosis determinants in renal disease: How much is homocysteine involved

Plant Antioxidants Participate in the Coordinated Protection of the Nervous System The nervous system is integrated with the entire human body, and plant-derived antioxidant substances are absorbed by the digestive system and then circulated throughout the body

Consequently, free radicals accumulate substantially in the substantia nigra, and cytotoxic substances that cannot be cleared aggregate within neurons, ultimately leading to cell death and DA neurons [57]