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Genetic variation in metallothionein and metal-regulatory transcription factor 1 in relation to urinary cadmium, copper, and zinc

2B, the CI values at the 1:8 combination ratio were consistently less than 1 across most fractionally affected (FA) levels, with the lowest CI at IC 50 , indicating a favorable synergistic effect of combination therapy

Therefore, NFE2L2 serves a crucial role in the transcriptional regulation of ferroptosis, primarily via the activation of genes that counteract cellular damage (61)