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Effects of polyphenol-rich interventions on sleep disorders: a systematic review and meta-analysis

Studies suggest that O 2 - and H 2 O 2 serve as inflammasome activating ROS, enhancing the activation and production of NLRP3 inflammasome in mouse glomeruli cells

Furthermore, macrophages were polarized into M1 (IFN- and LPS) or M2 (IL-4/IL-13) phenotypes, with and without IGFBP7 silencing

These risks highlight the need for individualized assessments before intervention, standardized dosing and duration, and long-term safety monitoring to ensure clinical applicability and minimize potential harms