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The December 2025 preprint discussed here is the first randomized controlled trial of the Bredesen approach

[Article] [PubMed]80

Coverage and requirements vary by plan and state

A pronounced enhancement of PI3K/AKT signaling and increased SCFA production was also observed after 12 weeks of oral administration of a Lactobacillaceae strain mixture, isolated from healthy human feces, to db/db mice