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Additionally, accelerated ATP degradation under pathological conditions (e.g., intense exercise and ischemiareperfusion injury) promotes hypoxanthine accumulation, creating a secondary drive for UA overproduction (Uskudar Cansu et al., 2019)

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DNA methylation is the process of adding methyl groups to the fifth carbon of cytidine (C5) or in the N6 position of adenine within the DNA strands, and it is considered the most frequent and stable epigenetic modification associated with silencing of gene transcription [6,7,8]