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4.4 Future perspectives: from mechanistic insight to clinical translation To fully harness the therapeutic potential of ferroptosis in kidney diseases, future research must address the aforementioned challenges through a combination of mechanistic depth, technological innovation, and clinical validation

Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies

They are primarily regulated by the transcription factor forkhead box P3 ( FOXP3 ), which is essential for their development, function and their suppressive activity, any mutations in the FOXP3 gene can impair the Tregs activity, leading to autoimmune disorders

GA combined with ursodeoxycholic acid can significantly reduce liver enzyme levels within 12 weeks and enhance the effectiveness of treatment for MASLD