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1 H-NMR (400 MHz, CDCl 3 ) ppm = 7.72 (dd, J = 0.6 Hz, J = 8.2 Hz, 1H, Ar-H), 7.66 (dd, J = 0.8 Hz, J = 1.8 Hz, 1H, Ar-H), 7.63 (dd, J = 0.6 Hz, J = 1.5 Hz, 1H, Ar-H), 7.40 (dd, J = 1.5 Hz, J = 8.2 Hz, 1H, Ar-H), 7.28 (dd, J = 0.8 Hz, J = 3.5 Hz, 1H, Ar-H), 6.60 (dd, J = 1.8 Hz, J = 3.5 Hz, 1H, Ar-H), 3.11 (bs, 3 H, -CH 3 ), 3.00 (bs, 3 H, -CH 3 )

Potential therapeutic strategies It has been reported that artesunate prevents brain damage at low doses by blocking ferroptosis, and iron chelators such as DFO and DFP have demonstrated positive effects against iron-related neurodegenerative disorders

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Dulbeccos Modified Eagles Medium (DMEM), fetal bovine serum (FBS), 0.25% trypsin, and penicillin-streptomycin (100) were purchased from Gibco (Grand Island, USA)

Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes