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In the study by Wang et al

Hodges RJ, Jenkins RG, Wheeler-Jones CP, Copeman DM, Bottoms SE, Bellingan GJ, Nanthakumar CB, Laurent GJ, Hart SL, Foster ML, McAnulty RJ (2004) Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E(2) production

This responsiveness is the International Sensitivity Index (ISI) and the formula used is as follows 4 : INR = (patient PT/mean normal PT) ISI The ACCP guidelines recommend an INR between 2.0 and 3.0 for venous thromboembolic and atrial fibrillation indications and an INR between 2.5 and 3.5 for mitral valve replacement

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Immunohistochemical specificity of anti-GPX1 was also evaluated in formalin-fixed paraffin sections from liver, breast and lung cancer, known to express GPX1 (Basnet et al