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5.2 PCs and type 2 diabetes mellitus Type 2 diabetes mellitus (T2DM) is recognized as a metabolic syndrome, primarily marked by insufficient insulin caused by pancreatic -cell dysfunction and insulin resistance in target organs (NCD Risk Factor Collaboration NCD-RisC, 2016

PLoS ONE 7 , e40015 (2012)

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These contrast with homeostatic levels (0.11 mM in humans/mice), establishing low (1 mM) and high (2 mM) thresholds for context-dependent function

It has been reported that cellular uptake of glutamine and its subsequent efflux in the presence of essential amino acids, including leucine, is the rate-determining step that activates mTORC1 191