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doi: 10.3389/fnut.2022.962312 Received 06 June 2022 Accepted 13 September 2022 Published 06 February 2023 Volume 9 - 2022 Edited by Xianli Gao, Jiangsu University, China Reviewed by Danjun Guo, Wuhan Polytechnic University, China

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However, a discovery that bacterial pore-forming toxins can induce necroptosis (a programmed necrosis) also in red blood cells (RBCs) is striking and could eventually lead to a re-conception of erythrocytes as entities between life and death [25]

However, supplementing solely with folic acid/folate can mask an underlying B12 deficiency