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WM, JS, XZ, YT, and YY contributed to the provided guidance of the whole manuscript

Also, the animal model used for induction of T2D and insulin resistance limits direct clinical extrapolation

Figures Abstract 1-Methylxanthine (1-MX) is the major metabolite of caffeine and paraxanthine and might contribute to their activity

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Previous studies have found that berberine inhibits cell death induced by 6-OHDA, and increases the expression of HO-1, ultimately protecting dopaminergic neurons (Kim et al., 2014)