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In fact, the high expression of glycogen synthase-1 in RA-FLSs can lead to the excessive accumulation of glycogen and inhibit AMPK expression, leading to the high expression of matrix metallopeptidase (MMP)-1, MMP-9, IL-6, and CCL-2, along with increased proliferation and migration of FLSs

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Behavioral assessments showed that lactoferrin- CAY10603-PLGA improved locomotor performance in the challenging beam and cylinder tests, while dopamine levels were increased to 8194 840 ng/g, compared to 591 103 ng/g in control mice