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The biological effects of polyphenol-rich ingredients often rely on synergistic interactions and microbiota-derived metabolites like the urolithins produced from pomegranate ellagitannins, which extend their activity and support systemic health, Zangara explained

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Cell Stress and Chaperones 27 , 121134 (2022)

Results BSO synergistically enhanced L-PAM-induced cytotoxicity in nine MM cell lines, in presence of BMSC and MM cytokines, and in seven primary MM cells We determined the cytotoxicity of clinically achievable levels of BSO (0400 M) and L-PAM (050 M) in nine human MM cell lines using the DIMSCAN cytotoxicity assay (Figure 1a)

The first step is to identify and eliminate the root cause(s) of an illness