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Acknowledgment The work in this study was supported by the Natural Science Foundation of China (grants 30971188, 81273279, 81302560, and 81373201)

Available from: [Accessed October 26, 2020]

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The resulting trimmed and de-duplicated reads were then aligned to the Rattus norvegicus Rnor6.0 reference genome, available on ENSEMBL, using STAR aligner v.2.5.2b4 25 , producing BAM files

Oral supplements: can work for mild deficiency and maintenance in people who absorb B12 normally, but tend to take longer and are less reliable when absorption is impaired