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However, it is important to note that curcumin has also been identified as a PAINS, exhibiting behaviors such as redox cycling, metal chelation, aggregation, and fluorescence interference that can artificially inflate its apparent bioactivity in vitro (Nelson et al., 2017)

64 In this phase III trial, 24 patients with chronic LBP unresponsive to conservative treatment for 6 months associated with 1- or 2-level IDD (Pfirrmann score 2-4) were randomly allocated to the experimental or the control group

In cancer treatment, genetic technologies include gene knockout and gene transfection methods (121)

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Since the body cannot store zinc, an adequate dietary zinc intake, estimated at 25 mg/day in adults, is recommended for maintaining normal thyroid function