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The high-mobility group box-1 (HMGB1) protein is a pro-inflammatory nuclear protein that is passively released and targets Toll-like receptors (TLR) to alert the immune system of dying cells (Lotze and Tracey 2005

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Their collective list includes the following: electronic health record (EHR) systems (with a time stamp) and electronic signatures, other electronic means, facsimile sheets/logs, paper records and paper logs (for example, physicians providing signatures at the nursing desk in a facility), electronic date stamps, call logs, tracking forms, and those POCs hand delivered to physicians (including to physicians in their offices or during weekly rounds in the facility)

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