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reduced glutathione detoxifies reactive oxygen species such as hydrogen peroxide, preventing them from causing oxidative stress ( Figure 1 )

ATF3 participates in various aspects of ferroptosis, influencing iron metabolism and lipid processing, and modifying cellular antioxidant defense mechanisms (114116)

One way, two way or repeated ANOVA and appropriate post-hoc tests were used to identify significant differences, with a significance level set at p 0.9999)

Furthermore, thiazolidinedione derivatives (e.g., rosiglitazone and pioglitazone) demonstrate selective inhibition of ACSL4, consequently attenuating ferroptosis progression (Sheng et al., 2024)