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These morphologic findings correlate with an early selective depolarization of the resting membrane potentiation, attributed to a decrease in the activity of the electrogenic Na + /K + -ATPase, that results in an enhancement of the efficacy of excitatory inputs to these interneurons (Ross and Soltesz, 2000)

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Despite varying phenotypes across patient-derived iPSC models of PD, their application in the pursuit of biomarkers or novel therapeutic compounds is still ongoing

Vormann J, Goedecke T

Dalton PD, Dieter MZ, Yang Y, Shertzer HG, Nebert DW: Knockout of the mouse glutamate cysteine ligase catalytic subunit ( Gclc ) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozyogous