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In extreme cases, neuropsychiatric effects (e.g., depression and confusion) and immune dysfunction appeared in more severe or prolonged deficiency

Blanco-Mguez A, Beghini F, Cumbo F, McIver LJ, Thompson KN, Zolfo M, et al

Ferroptosis is characterized by impaired synthesis of antioxidant and free radical scavenger GSH, and it is a new form of programmed cell death distinct from apoptosis [36, 58]