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When beginning treatment, your body is adjusting to a new hormonal pulse

If your symptoms intensify rather than improve after two weeks, stop use and consult a dermatologist

This detrimental effect, however, could be prevented by treatment with the beta-blocker carvedilol in rats

The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study