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These effects may alter the dose of the drug needed to reach the desired blood concentration and induce novel toxicities

Plant Cell Physiol 62(5):913921

Elders GJ, Blumenthal SL, Guyer RD, Hochschuler SH, Rashbaum RF, Sachs BL, Zigler JE, Ohnmeiss DD: Effect of Facet Joint Arthrosis on Outcome after Artificial Disc Replacement

6.2 Anti-inflammatory and Immunomodulatory applications Curcumin exerts notable anti-inflammatory effects by modulating multiple signaling pathways, including NF-B, MAPK, and pro-inflammatory cytokine cascades [156]