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Additionally, through EC-secreted factors (chemoattractant and adhesion molecules), ECs enhance leukocyte infiltration

with or without Lgr5 DTR-EGFP/+ mice were also treated with Tamoxifen three times on day 1, day 0 and day 1 for continuous 3 days in order to fully label ALP+ enterocytes before induction of enteritis, which was initiated by intraperitoneal administration of 5-FU;(200 mg/kg body weight

Serotonin and the GI tract

Upon TGF- attachment, ALK1 is induced to form a complex with ALK5, resulting in Smad1/5 activation (Finnson et al., 2008

Additionally, Diquat activates the NF-B signaling pathway, leading to the massive release of pro-inflammatory cytokines (such as TNF-, IL-6, and IL-1)