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Cyclooxygenase-2 (COX-2) is an essential enzyme of prostaglandin synthesis encoded by the PTGS2 gene [88]

Dull or uneven skin tone Those seeking a quick brightening effect Individuals with melasma, pigmentation, dark spots Anyone wanting a light, daytime cream with glow Instant toneup is cosmetic: The brightening effect can be partly from pigmentationdiffusing pigments that create a lighter look, not permanent lightening

Oberley TB, Oberley LW (1997)

xanthohumol (XN), a ligand of PHB2, inhibits autophagic degradation of mitochondria through association with PHB2 binding and inhibiting the binding of PHB2 to LC3, which in turn inhibits mitophagy (Fig