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Treatment is usually oral doxycycline for acute or mild disease

References Ali YS, Shaw I, Nie C et al (2026) Microfluidics-engineered mannitol- stabilized solid lipid nanoparticle hydrogel for enhanced topical delivery of apremilast in psoriasis therapy

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Lastly, while the exclusion of patients with specific co-morbid conditions creates a high degree of illness specificity, it does not preclude the clinical reality that Lyme disease and its associated persistent sequelae often occur in the context of other pre-existing conditions