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Such studies remind us that negative or nuanced outcomes are often the most enlightening, pushing the field forward and helping refine both scientific questions and clinical practice

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Enhanced oxidative capacity may involve increased mitochondrial fatty acid uptake via carnitine palmitoyltransferase-1 (CPT-1), enhanced beta-oxidation enzyme expression, and modulation of uncoupling protein expression

Nuclear factor erythroid 2-related factor 2 (Nrf2) as the key transcription factor playing an essential role in redox balance and depleted in COPD patients (Deshmukh et al., 2017), modulates the expression of approximately 100 genes functioning the state of redox, inducing the transcription of glutathione (GSH) (Osburn et al., 2006)