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This loss of chronobiological responsiveness stems both from the desynchronization between central and peripheral clocks, and from the chronotype heterogeneity observed with aging, as the geriatric tendency toward morning chronotypes may not align with dosing regimens designed for younger adults with evening chronotypes (Kara et al., 2023)

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ChenXLiXZhangWHeJXuBLeiBet alActivation of AMPK inhibits inflammatory response during hypoxia and reoxygenation through modulating JNK-mediated NF-B pathway

Core functions of skeletal cells Osteoblast: Derived from bone marrow mesenchymal stem cells, responsible for synthesizing bone matrix (type I collagen, osteocalcin, bone alkaline phosphatase), promoting calcium and phosphorus deposition, and constructing new bone, it is the core driving force of bone formation