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Renal dysfunction does not affect lidocaine HCl kinetics but may lead to increased accumulation of metabolites

Melittin in BV has antibacterial properties (Elieh Ali Komi et al., 2018)

Upon reaching the infection site, the overexpressed bacterial gelatinase degrades the gelatin core, triggering the controlled release of vancomycin and enabling site-specific antibacterial action [90]

Melatonin, secreted by the pineal gland in response to darkness, plays a key role in maintaining circadian homeostasis and exhibits broad oncostatic properties 19

This includes those with undernutrition or malnutrition, including the elderly, who are more at risk for nutrient deficiencies as well as are those who have excess weight or chronic disease