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[7377] In elegant work on AAT, Hayashi and coworkers have shown that ground state destabilization occurs in the free enzyme through strain imposed on the internal aldimine, which increases the value of k cat /K M .[24] Additional strain is present in the Michaelis complex with amino acids induced by domain closure

This protective action helps maintain skin health over time and prevents the accumulation of damage that can lead to visible signs of aging and skin problems

However, to date, information on microbiota-associated GRP metabolism is insufficient

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