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Drug repurposing, in which drugs are used for the treatment of diseases for which they were not originally developed, can represent an alternate and more efficient drug development pipeline to allow for more rapid advancement of therapies for clinical use [6]

Furthermore, several studies have confirmed that the overexpression and hyperphosphorylation of Tau can lead to iron overload, thereby inducing ferroptosis [154]

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In addition to reducing NO release and impairing vasodilation, RhoA/ROCK pathway regulates the vascular endothelium of the CC by modulating endothelial cell contraction and disrupting endothelial barrier function