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[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Tran TD, Biggs B-A, Holton S, Nguyen HTM, Hanieh S, Fisher J

Kynurenine Pathway Pathologies: do Nicotinamide and Other Pathway Co-Factors have a Therapeutic Role in Reduction of Symptom Severity, Including Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)

Through systematic mutagenesis, they established that the unique glutamate residue (E343), which replaces the histidine conserved in most other SLC39A/ZIP transporters mentioned above, along with residue D410, is essential for Mn binding and transport

This activity may be driven by increased levels of brain-derived neurotrophic factor (BDNF) or through a more direct modulation of specific receptors that govern cognitive processes

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