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None of the patients were being evaluated for transplantation at the time of MRX initiation

In granulosa cells of women with endometriosis, elevated lipid peroxidation markers such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) have been observed, accompanied by decreased glutathione (GSH) and glutathione peroxidase 4 (GPx4), key inhibitors of ferroptosis ( Ferroptosis exerts a double-edged effect in endometriosis: while it damages ovarian granulosa cells, oocytes, and embryosdisrupting oocyte maturation, decreasing oocyte retrieval rates, and impairing embryonic developmentit also promotes ectopic lesion growth through downstream signaling pathways that enhance angiogenesis and inflammation ( Therapeutically, ferroptosis inducers can promote lipid ROS accumulation and endometriotic cell death but may exacerbate granulosa cell damage, while ferroptosis inhibitors protect granulosa cells against oxidative damage

146,147 Special care is needed with natural and OTC compounds, as they may have unreliable safety or pharmacokinetic profiles, requiring more stringent trials before approval for a major CV indication

Nonetheless, the SBDs of ABC importers on the extracellular portion helps in capturing and delivering the transported substrate to the MSDs (61)

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