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After thorough safety and efficacy evaluations, along with in vivo and in vitro model studies, the most promising antifungal compounds in preclinical and clinical development include novel triazoles, glucan synthase inhibitors, and small-molecule polypeptides

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Conversely, other PK studies imply that increasing age has no effect on toxicity [68,69,70,71,72]

Auditory neurons compensate for deafferentation by increasing their input/output functions (gain) at multiple levels of the auditory system

Although biochemically separated from the GSH system, the Trx system shares NADPH as a common reducing cofactor and serves as an alternative pathway for reducing disulfide bonds, making this system especially relevant if the GSH system has been compromised or rendered dysfunctional (Silva-Adaya et al., 2014)