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Semax is injected once daily in the morning, five days on and two days off, for a full 2-month cycle followed by a 2-month rest

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Bertero, T., Oldham, W

and anti--actin antibody (Abcam, Cambridge, MA)

However, as CD4 + T cells are the major mediators of CNS injury during the course of EAE, in studies of human MS, in which conspicuous CD8 + T cells are infiltrated throughout lesions at all stages, whereas CD4 + T cells are sparse or even absent, an added challenge for determining the precise role of CD4 + T cells is ascertaining whether these effectors are more critical in disease initiation than in established MS ( + T cells has provided definitive evidence of clinical efficacy (87)