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A third widely-cited paper (McCoy 2013, PMID 23055539) the source of the often-repeated "seven orders of magnitude more potent than BDNF" line carries a 2021 Expression of Concern

While fibroblasts are normally quiescent when responding to injury or inflammation, they upregulate their cytoskeletal components and differentiate into highly contractile myofibroblasts [113] and increase their deposition of collagen and ECM into the tissues

Caplan has been ahead of her time in medicine since I have been seeing her over the last 30 years

A genetically encoded tool for manipulation of NADP(+)/NADPH in living cells

Tendon and ligament repair: Animal studies demonstrate accelerated healing of tendons and ligaments, which explains its popularity for joint and connective tissue injuries