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A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate (CDDO-Me): direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis

Biol Psychiatry 68(7):667670 Marsman A, Mandl RC, Klomp DW, Bohlken MM, Boer VO, Andreychenko A, Cahn W, Kahn RS, Luijten PR, Hulshoff Pol HE (2014) GABA and glutamate in schizophrenia: a 7 T 1 H-MRS study

177 Additionally, through S6K1, mTORC1 facilitates the phosphorylation and activation of the CAD complex, which is the rate-limiting step in pyrimidine biosynthesis