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The key difference lies in location and appearance

Several studies have suggested a cooperative link between HIFs and NRF2 in cancer metastasis

Recently report address that GH inhibits DNA damage repair by suppressing ATM and DNA-PKcs activities in colon cells, leading to decreased DNA repair by both HR and NHEJ ( In vivo , injecting hGH to human subjects for 6 weeks results in increased lymphocyte DNA damage, and the damage can last for a long time after hGH withdrawal ( IGF1 Promotes DNA Damage Repair of DNA DBSs IGF1 and IGF1R are necessary for nucleotide excision repair (Loesch et al., 2016)

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Those homozygous have only ~30% normal enzyme activity. Methylfolate bypasses the problem