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What sets it apart from earlier compounds in the same category is its selectivity: it triggers GH release without meaningfully raising cortisol, prolactin, or other hormones that older secretagogues like GHRP-2 and GHRP-6 tended to drag up

In severe cases, a deficiency can even lead to a swollen and inflamed tongue and mouth, known as glossitis

This suggests that neuronal degeneration may lead to local release of iron, which is subsequently scavenged and stored by microglia to maintain brain iron homeostasis (346)

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

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