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Evidence level: Unsupported by the cited record Sources: Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice., Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction., ClinicalTrials.gov exact-name search, accessed 2026-07-12 How to read this: Direct efficacy findings come from obese mice, not human trials

There is no published evidence base for cycles longer than 24 weeks, so any extended use is unsupported by trial data

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