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PepPal (2026) 7

Notably, such effects are mediated by the phosphorylation-dependent activation of the calcium/cAMP response element binding protein (CREB) that binds to calcium/cAMP regulatory elements (CREs) on DNA

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Among the conventional routes of drug delivery to the retina, including the topical, intravitreal, periocular, suprachoroidal, and systemic routes, intravitreal injection (IVI) is the preferred one [6]