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The key distinction is that conventional treatments primarily target hormonal pathways (suppressing estrogen), while GLP-1 agonists target inflammatory and metabolic pathways

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In general, the production of ROS increases with aging and is associated with DNA damage to the tissues

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here, the variant forms of the gene may lead to altered transcription of the gene such that the final protein is expressed in abnormal amounts (compared with the amounts produced by individuals carrying the more common, or wild-type, allele)