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NRF2 is tightly regulated at different levels by epigenetic modifications such as OS, inflammation, and different forms of stress [148], and has regulatory functions in mitochondrial biogenesis and cellular energy metabolism [149]

gingivalis colonization at the gingival margin and adjacent alveolar bone, a setting in which bacterial virulence and host inflammatory responses promote iron accumulation, mitochondrial dysfunction, lipid peroxidation and ultimately ferroptotic cell death