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It should be noted that while ingested curcumin is cleared rapidly, which is considered disadvantageous, however the amount of administered curcumin (3600 mg daily) conferred sufficient anti-oxidant activity in human intestinal tract to result in pharmacodynamic changes corresponding to intestinal chemopreventions [414, 415]

Nevertheless, the limited targeting capacity of conventional drugs results in suboptimal drug concentrations at sites of active intestinal inflammation, thereby restricting therapeutic effectiveness

Redox Biol 37:101715 Zhang J, Wang H, Yan X, Zhang L (2005) Comparison of short-term toxicity between Nano-Se and selenite in mice

Amongst others, it processes metabolites from tobacco , alcohol and therapeutic drugs