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Upon targeting efflux transporters, reprogramming cancer metabolism, inducing mitochondrial apoptosis, and synergizing with chemotherapeutic agents, berberine exhibits the multi-faceted nature of drug resistance

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Prog Retin Eye Res 36, 199216

Despite current standard treatment involving maximal surgical resection followed by radiotherapy and temozolomide (TMZ)-based chemotherapy, the median survival time remains less than 15 months for most patients [3,4,5,6]

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