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Aguilar-Daz H, Bobes RJ, Carrero JC, Camacho-Carranza R, Cervantes C, Cevallos MA, et al

doi: 10.1146/annurev-pathmechdis-031521030435 40 ZhaoWHuYLiCLiNZhuSTanXet al

In elderly organisms, the balance between these phenotypes may shift, leading to heightened inflammation

Mol Biol Rep 48(9):65396550 Tibullo D, Li Volti G, Giallongo C, Grasso S, Tomassoni D, Anfuso CD, Lupo G, Amenta F, Avola R, Bramanti V (2017) Biochemical and clinical relevance of alpha lipoic acid: antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential

Epidemiological evidence associates reduced gut microbiota diversity with increased incidence of metabolic disorders (obesity, diabetes), cardiovascular pathologies, and immune-mediated conditions including allergic diseases (Shi et al., 2024)