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LPS activates macrophages through TLR 4, prompting the release of inflammatory factors such as IL-1 and TNF- , which drive Th 1 differentiation and promote IFN- secretion, further magnifying local inflammation in the thyroid gland (Zhang et al., 2023)

Specifically, ATF3 enhances macrophage clearance of Staphylococcus aureus by directly binding to the promoters of antimicrobial peptide genes, such as Reg3 and S100A8/9, to bolster host defense (198)