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Emerging evidence also implicates age-related bloodbrain barrier disruption and gutbrain axis dysregulation as additional modulators of synaptic integrity via immune, metabolic, and neurochemical pathways

The genetic combinations used in the assays were generated by standard genetic crosses

Kaji R, et al

The agency declined to evaluate three of them, writing that the nominations did not include sufficient information and that it did not identify clinical studies using BPC-157 in these populations. The 68-page review is entirely about ulcerative colitis, because thats the only proposed use with any human trial behind it