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doi: 10.1158/1538-7445.SABCS22-OT2-03-02 [DOI] [Google Scholar] 247

Our previously used concentrations of sertraline in pre-clinical in vivo experiments with anti-cancer effects can be extrapolated to the concentrations used in humans, showing a therapeutic index of sertraline that could support future clinical trials [19, 23, 24]

This cost can be prohibitive, especially in large-scale studies or clinical applications where significant quantities of antibodies are required (Klutz et al., 2016)